第1）、2）两点是以下论文的生物数据库搜索匹配结论：
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
（SARS-CoV-2策略性地模拟人类ENaC的蛋白水解激活） https://elifesciences.org/articles/58603
论文原文：
Now, Anand et al. show that the spike proteins on SARS-CoV-2 may have the same sequence of amino acids at its cut site as a human epithelial channel protein called EnaC-α.
…
SARS-CoV-2 contains an 8-mer peptide that is identical to the furin cleavage site in the α subunit of ENaC located at the C-terminal end of the putative inhibitory segment.
…
Hence, the authors should better stress the novelty of their paper, which resides in the correlation be-tween this cleavage site that is present only in SARS-CoV-2 (and not in other coronaviruses) and the ENAC-α,
…
The resulting tribasic 8-mer peptide (RRARSVAS) on the SARS-CoV-2 S1/S2 site is conserved among 10,956 of 10,967 circulating strains deposited at GISAID (https://www.gisaid.org/) (Elbe and Buckland-Merrett, 2017), as of April 28, 2020 (Supplementary file 1a). This peptide is also absent in over 13,000 non-COVID-19 coronavirus S-proteins from the VIPR database (Carrillo-Tripp et al., 2009). Strikingly, examining over 10 million peptides (8-mers) of 20,350 canonical human proteins from UniProtKB shows that the peptide of interest (RRARSVAS) is present exclusively in human ENaC-ɑ, also known as SCNN1A (p-value=4E-4) (see Materials and methods).
The FCS sequence of human ENaC α (20) is identical in chimpanzee, bonobo, orangutan, and gorilla (SI Appendix, Fig. 1), but diverges in all other species, even primates, except one. (The one non-human non-great ape species with the same sequence is Pipistrellus kuhlii, a bat species found in Europe and Western Asia; other bat species, including Rhinolophus ferrumequinem, have a different FCS sequence in ENaC α [RKAR'SAAS]).
莫德纳专利US 9587003中的SEQ ID11652序列可能引入了人和小鼠肿瘤中的核苷酸，或者说，SEQ ID11652可能修改了正常人类MSH3中氨基酸的核苷酸密码子，代之以肿瘤组织中MSH3氨基酸的核苷酸密码子。而来自肿瘤组织的核苷酸已被证明可使小鼠产生多种癌症。注意专利中的以下两段文字：
Lacour, F. et al., Transplantable malignant tumors in mice induced by preparations containing ribonucleic acid extracted from human and mouse tumors. J. Natl Cancer Inst., 1960, 24(2):301-27. cited by applicant .
Latarjet, R., Production of multiple cancers in mice having received nucleic acid extract from isologous & homologous leukemic tissues. C.R. Hebd Seances Acad. Sci., 1958, 246(5):853-5. cited by applicant .
这两段的机器译文：
Lacour, F. 等人，用含有从人和小鼠肿瘤中提取的核糖核酸的制剂诱发小鼠的可移植性恶性肿瘤。 J.国家癌症研究所，1960，24(2)：301-27。 申请人引用。
SARS-CoV-2、MERS-CoV P5位点皆为脯氨酸，这是极不寻常的。furin切割序列P5位点极少出现脯氨酸，Thomas Lemmin等人发表的以下论文指出，在已识别的132个furin切割序列中，仅有5个序列P5位点为脯氨酸。
Structures and dynamics of the novel S1_S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein
SARS-CoV-2刺突糖蛋白新型S1_S2蛋白酶切割位点环的结构和动力学 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534663/
论文原文：
it appears that a proline residue at position P5, i.e., the 5th residue prior to the furin cleavage site, is rare and appears in only 5 out of 132 sequences (three mammalian and two viral sequences).
论文原文：
We scanned the human databases (Taxon 9606) and found that the exact sequence PRRARS was present only in two human proteins: AAB17869.1, Hermansky-Pudlak syndrome protein (HPS1), and AAF79955.1, RhoGEF. There are 17 isoforms of HPS1; incidentally, RhoGEF in the curated UniProt data does not carry this motif (Supplemental Table 1).
两种含有PRRARS序列的人类蛋白是HPS1 （Hermansky-Pudlak syndrome protein 1）和RhoGEF，某些生物库（如UniProt ）中的RhoGEF蛋白不包含PRRARS序列。
